Method for preparing malonate methylidene nanoparticles, nanoparticles optionally containing one or several biologically active molecules

The invention relates to a method for the preparation of nanoparticles formed from a random polymer of at least one compound of formula (I) group R1 and R2, identical or different, represents a linear or branched C1-C6 alkyl group; n=1, 2, 3, 4 or 5, characterised in that the monomer is dissolved be...

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Bibliographic Details
Main Authors LESCURE FRANCOIS, COUVREUR PATRICK, GUILLON XAVIER, RIESS GERARD, BRETON PASCAL, ROQUES-CARMES CLAUDE, BRU-MAGNIEZ NICOLE
Format Patent
LanguageEnglish
Published 05.07.2001
Edition7
Subjects
CHEMISTRY
COMPOSITIONS BASED THEREON
HUMAN NECESSITIES
HYGIENE
MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVINGCARBON-TO-CARBON UNSATURATED BONDS
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC MACROMOLECULAR COMPOUNDS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
THEIR PREPARATION OR CHEMICAL WORKING-UP
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Summary:The invention relates to a method for the preparation of nanoparticles formed from a random polymer of at least one compound of formula (I) group R1 and R2, identical or different, represents a linear or branched C1-C6 alkyl group; n=1, 2, 3, 4 or 5, characterised in that the monomer is dissolved beforehand in a water-miscible aprotic organic solvent forming, with the polymerization medium, a non-solvent mixture of the polymer formed. The invention also relates to said nanoparticles, which optionally contain one or more biologically active molecules, and the pharmaceutical compositions containing them.
Bibliography:Application Number: US20010770303