Escherichia coli compositions and methods thereof

In one aspect, the invention relates to an immunogenic composition comprising modified O-polysaccharide molecules derived from E. coli lipopolysaccharides and conjugates thereof. Multivalent vaccines may be prepared by combining two or more monovalent immunogenic compositions for different E. coli s...

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Main Authors Singh, Suddham, Chu, Ling, Kim, Jin-Hwan, Merchant, Nishith, Takane, Karen Kiyoko, Lomberk, Scott Ellis, Anderson, Annaliesa Sybil, Chen, Wei, Chorro, Laurent Oliver, Lotvin, Jason Arnold, Moran, Justin Keith, Prasad, Avvari Krishna, Donald, Robert G. K, Kodali, Srinivas, Pan, Rosalind, Gu, Jianxin, Ruppen, Mark Edward
Format Patent
LanguageEnglish
Published 29.10.2024
Subjects
CHEMISTRY
COMPOSITIONS BASED THEREON
DERIVATIVES THEREOF
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC MACROMOLECULAR COMPOUNDS
POLYSACCHARIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
THEIR PREPARATION OR CHEMICAL WORKING-UP
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Summary:In one aspect, the invention relates to an immunogenic composition comprising modified O-polysaccharide molecules derived from E. coli lipopolysaccharides and conjugates thereof. Multivalent vaccines may be prepared by combining two or more monovalent immunogenic compositions for different E. coli serotypes. In one embodiment, the modified O-polysaccharide molecules are produced by a recombinant bacterium that includes a wzz gene.
Bibliography:Application Number: US202217672126