Isoindolinone inhibitors of the MDM2-P53 interaction having anticancer activity

• Main Authors: Peach, Joanne, Noble, Martin Edward Mäntylä, Mitchell, Dale Robert, Cano, Celine Florence, Miller, Duncan Charles, Osborne, James Daniel, Whittaker, Benjamin Paul, Chessari, Gianni, Cons, Benjamin David, Holvey, Rhian Sara, Tamanini, Emiliano, Lewis, Arwel, Buck, Ildiko Maria, Griffin, Roger John, Watson, David Wyn, Hirst, Kim Louise, Rees, David Charles, St. Denis, Jeffrey David, Golding, Bernard Thomas, Hardcastle, Ian Robert, Johnson, Christopher Norbert, Howard, Steven
• Format: Patent
• Language: English
• Published: 27.08.2024
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention provides a compound of formula (I):or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims.Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds.