Formulations and methods for contemporaneous stabilization of active proteins during spray drying and storage

• Main Authors: Lucien, Rud Karly, Arya, Michelle, Liu, Qiyong Peter, Cui, Junqing, Carney, Ryan, Sohn, Jihae, Khan, Abdul W
• Format: Patent
• Language: English
• Published: 20.08.2024
• Subjects: ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; BLASTING; CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY; CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS,e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES,DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; CONVEYING; DRYING; DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM; HANDLING THIN OR FILAMENTARY MATERIAL; HEATING; HUMAN NECESSITIES; HYGIENE; LIGHTING; MECHANICAL ENGINEERING; MEDICAL OR VETERINARY SCIENCE; PACKAGES; PACKAGING ELEMENTS; PACKING; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; STORING; THEIR RELEVANT APPARATUS; TRANSPORTING; WEAPONS

A method of treatment of plasma with a physiologically compatible spray dry stable acidic substance (SDSAS) prior to or contemporaneously with spray drying of the plasma that results in greater recovery and greater long-term stabilization of the dried plasma proteins as compared to spray dried plasma that has not be subject to the formulation method of the present invention, as well as compostions related to plasma dried by the methods of the present invention.