Pyridine derivatives with c-linked cyclic substituents as cGAS inhibitors

The invention relates to new proline derivatives of formula (I) as cGAS inhibitors,whereinR1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and G are defined as in claim 1,and prodrugs or pharmaceutically acceptable salts of these compoundsfor the treatment of diseases such as systemic lupus erythematosus, sy...

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Main Authors Heimann, Annekatrin Charlotte, Theis, Theodor, Godbout, Cédrickx, Kley, Joerg, Gross, Patrick, Grundl, Marc, Gnamm, Christian, Hoenke, Christoph, Stuber, Raphael, Handschuh, Sandra Ruth, Kuttruff, Christian Andreas, Reinert, Dirk
Format Patent
LanguageEnglish
Published 23.07.2024
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention relates to new proline derivatives of formula (I) as cGAS inhibitors,whereinR1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and G are defined as in claim 1,and prodrugs or pharmaceutically acceptable salts of these compoundsfor the treatment of diseases such as systemic lupus erythematosus, systemic sclerosis (SSc), non-alcoholic steatotic hepatitis (NASH), interstitial lung disease (ILD) and idiopathic pulmonary fibrosis (IPF).
Bibliography:Application Number: US202217741050