Semisynthetic methods of preparing GTX1,4 and neosaxitoxin

Semisynthetic methods of preparing neosaxitoxin from cultures of the dinoflagellates Alexandrium pacificum and Gymnodinium catenatum are described. The scalable method includes the reductive desulfonation of an unresolved mixture of gonyautoxin 1 (GTX1) and gonyautoxin 4 (GTX4) using dithiol in a bu...

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Bibliographic Details
Main Authors Selwood, Andrew Ian, Van Ginkel, Roelof, Waugh, Craig Alan
Format Patent
LanguageEnglish
Published 25.06.2024
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:Semisynthetic methods of preparing neosaxitoxin from cultures of the dinoflagellates Alexandrium pacificum and Gymnodinium catenatum are described. The scalable method includes the reductive desulfonation of an unresolved mixture of gonyautoxin 1 (GTX1) and gonyautoxin 4 (GTX4) using dithiol in a buffered reaction solvent at a pH of about 7.5.
Bibliography:Application Number: US202117212690