Method of manufacturing bispecific antibodies, bispecific antibodies and therapeutic use of such antibodies

The invention relates to bivalent bispecific monoclonal antibodies (bbmAb) or variants thereof, and methods of manufacturing such antibodies by co-expressing modified Fc-mutated derivatives of two different monoclonal antibodies in mammalian cell lines.

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Bibliographic Details
Main Authors Graf, Christian, Jostock, Thomas, Oliver, Stephen John, Knopf, Hans-Peter, Koehler, Rolf, Kovarik, Jiri, Heitmann, Daniel, Buch, Tina, Woisetschlaeger, Maximilian, Bardroff, Michael Otto, Patel, Dhavalkumar
Format Patent
LanguageEnglish
Published 21.05.2024
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention relates to bivalent bispecific monoclonal antibodies (bbmAb) or variants thereof, and methods of manufacturing such antibodies by co-expressing modified Fc-mutated derivatives of two different monoclonal antibodies in mammalian cell lines.
Bibliography:Application Number: US202016844999