Anti-PD-L1 and IL-2 cytokines

• Main Authors: Arkinstall, Stephen John, Germaschewski, Volker, Gillies, Stephen Douglas, Kirby, Ian, Gallagher, Thomas, Deantonio, Cecilia, Van Krinks, Cassandra, Campbell, Jamie, Sandy, Nikole, Kosmac, Miha
• Format: Patent
• Language: English
• Published: 23.04.2024
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The present invention relates to anti-PD-L1 antibodies, bispecific antibodies containing one domain with specificity to PD-L1, and to immunocytokines comprising an anti-PD-L1 antibody fused to a cytokine, such as IL-2. The present invention also provides methods of treatment, uses and pharmaceutical...