Anti-PD-L1 and IL-2 cytokines

The present invention relates to anti-PD-L1 antibodies, bispecific antibodies containing one domain with specificity to PD-L1, and to immunocytokines comprising an anti-PD-L1 antibody fused to a cytokine, such as IL-2. The present invention also provides methods of treatment, uses and pharmaceutical...

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Bibliographic Details
Main Authors Arkinstall, Stephen John, Germaschewski, Volker, Gillies, Stephen Douglas, Kirby, Ian, Gallagher, Thomas, Deantonio, Cecilia, Van Krinks, Cassandra, Campbell, Jamie, Sandy, Nikole, Kosmac, Miha
Format Patent
LanguageEnglish
Published 23.04.2024
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention relates to anti-PD-L1 antibodies, bispecific antibodies containing one domain with specificity to PD-L1, and to immunocytokines comprising an anti-PD-L1 antibody fused to a cytokine, such as IL-2. The present invention also provides methods of treatment, uses and pharmaceutical compositions comprising the antibodies, bispecific antibodies and immunocytokines.
Bibliography:Application Number: US201716311434