Antigen-binding molecule comprising altered antibody variable region binding CD3 and CD137

Antigen-binding domains that are capable of binding to CD3 and CD137 but do not bind to CD3 and CD137 at the same time and methods of using the same are provided. Methods to obtain antigen binding domains which bind to two or more different antigen more efficiently are also provided.

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Bibliographic Details
Main Authors Ho, Shu Wen Samantha, Miyazaki, Taro, Sakurai, Mika, Igawa, Tomoyuki, Shimizu, Shun, Hironiwa, Naoka
Format Patent
LanguageEnglish
Published 09.04.2024
Subjects
CHEMISTRY
COMBINATORIAL CHEMISTRY
LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Summary:Antigen-binding domains that are capable of binding to CD3 and CD137 but do not bind to CD3 and CD137 at the same time and methods of using the same are provided. Methods to obtain antigen binding domains which bind to two or more different antigen more efficiently are also provided.
Bibliography:Application Number: US201816769299