Compounds and compositions for inhibiting the activity of SHP2

The present invention relates to compounds of formula I:in which Y1, Y2, R1, R2 and R3 are defined in the Summary of the Invention; capable of inhibiting the activity of SHP2. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comp...

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Main Authors Karki, Rajesh, Smith, Troy Douglas, Majumdar, Dyuti, Perez, Lawrence Blas, Fortanet, Jorge Garcia, Yang, Fan, Chen, Zhuoliang, Lamarche, Matthew J, Sendzik, Martin, Yu, Bing
Format Patent
LanguageEnglish
Published 20.02.2024
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The present invention relates to compounds of formula I:in which Y1, Y2, R1, R2 and R3 are defined in the Summary of the Invention; capable of inhibiting the activity of SHP2. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of diseases or disorders associated with the aberrant activity of SHP2.
Bibliography:Application Number: US202017130374