6-6 bicyclic aromatic ring substituted nucleoside analogues for use as PRMT5 inhibitors
The present invention relates novel 6-6 bicyclic aromatic ring substituted nucleoside analogues of Formula (I)wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as PRMT5 inhibitors. The invention further relates to pharmaceutical...
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Format | Patent |
Language | English |
Published |
30.01.2024
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Abstract | The present invention relates novel 6-6 bicyclic aromatic ring substituted nucleoside analogues of Formula (I)wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as PRMT5 inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament. |
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AbstractList | The present invention relates novel 6-6 bicyclic aromatic ring substituted nucleoside analogues of Formula (I)wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as PRMT5 inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament. |
Author | Wu, Tongfei Viellevoye, Marcel Schepens, Wim Bert Griet Pande, Vineet Beke, Lijs Meerpoel, Lieven Gilissen, Ronaldus Arnodus Hendrika Joseph Lawson, Edward Charles Brehmer, Dirk Diels, Gaston Stanislas Marcella Boeckx, An Thuring, Johannes Wilhelmus John F Sun, Weimei Paradé, Marcus Cornelis Bernardus Catharina |
Author_xml | – fullname: Brehmer, Dirk – fullname: Lawson, Edward Charles – fullname: Boeckx, An – fullname: Diels, Gaston Stanislas Marcella – fullname: Wu, Tongfei – fullname: Meerpoel, Lieven – fullname: Beke, Lijs – fullname: Thuring, Johannes Wilhelmus John F – fullname: Gilissen, Ronaldus Arnodus Hendrika Joseph – fullname: Schepens, Wim Bert Griet – fullname: Viellevoye, Marcel – fullname: Pande, Vineet – fullname: Sun, Weimei – fullname: Paradé, Marcus Cornelis Bernardus Catharina |
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Snippet | The present invention relates novel 6-6 bicyclic aromatic ring substituted nucleoside analogues of Formula (I)wherein the variables have the meaning defined in... |
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SubjectTerms | AGRICULTURE ANIMAL HUSBANDRY BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES CHEMISTRY FISHING FORESTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HUNTING HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEST REPELLANTS OR ATTRACTANTS PLANT GROWTH REGULATORS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS TRAPPING |
Title | 6-6 bicyclic aromatic ring substituted nucleoside analogues for use as PRMT5 inhibitors |
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