6-6 bicyclic aromatic ring substituted nucleoside analogues for use as PRMT5 inhibitors

• Main Authors: Brehmer, Dirk, Lawson, Edward Charles, Boeckx, An, Diels, Gaston Stanislas Marcella, Wu, Tongfei, Meerpoel, Lieven, Beke, Lijs, Thuring, Johannes Wilhelmus John F, Gilissen, Ronaldus Arnodus Hendrika Joseph, Schepens, Wim Bert Griet, Viellevoye, Marcel, Pande, Vineet, Sun, Weimei, Paradé, Marcus Cornelis Bernardus Catharina
• Format: Patent
• Language: English
• Published: 30.01.2024
• Subjects: AGRICULTURE; ANIMAL HUSBANDRY; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES; CHEMISTRY; FISHING; FORESTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HUNTING; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; TRAPPING

The present invention relates novel 6-6 bicyclic aromatic ring substituted nucleoside analogues of Formula (I)wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as PRMT5 inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.