Terminal sterilization filtration closed lyophilization in a container

• Main Authors: Doty, Mark Joseph, Hristakos, Anastasios, Cope, Sydney Jean, Hurst, William Spencer, Bomgaars, Grant Anthony, Krause, Bernd, Ding, Yuanpang Samuel, Ranalletta, Joseph Vincent, Sadowski, Michael Joseph, Dudar, Thomas Edward, Rebbeck, Christine L, Pasmore, Mark Edward, Lo, Ying-Cheng
• Format: Patent
• Language: English
• Published: 05.12.2023
• Subjects: BABY COMFORTERS; BLASTING; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICALPURPOSES; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; DEVICES FOR RECEIVING SPITTLE; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGINGPHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL ORADMINISTERING FORMS; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; DRYING; DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM; HEATING; HUMAN NECESSITIES; HYGIENE; LIGHTING; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MECHANICAL ENGINEERING; MEDICAL OR VETERINARY SCIENCE; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL; WEAPONS

A sterile solution product bag for lyophilizing includes a bladder, a first stem having a first stem inlet end and a first stem outlet end. The first stem outlet end is fluidly connected to the bladder and the first stem inlet end is adapted to receive a liquid. A first filter is disposed in-line with the first stem and includes a first filter membrane, a first filter open end, and a first filter closed end. The first filter closed end is disposed between the first stem inlet end and the first stem outlet end and the first filter open end is disposed in proximity to the first stem inlet end. A second stem having a second stem inlet end fluidly connected to the bladder and a second stem outlet end adapted to receive a vapor. A second filter is disposed within the second stem and includes a filter membrane.