Purification method and device for continuous distillation and separation of ibuprofen intermediate raw material

• Main Authors: Wang, Yinglong, Cui, Peizhe, Zhu, Zhaoyou, Du, Deping, Wang, Kaiguang, Li, Xin, Qi, Jianguang, Xu, Wenhui, Zheng, Zhonghui, Zhong, Limei, Jia, Jianbo
• Format: Patent
• Language: English
• Published: 21.11.2023
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY

The present disclosure belongs to the technical field of chemical separation and purification, and in particular relates to a purification method and device for continuous distillation and separation of an ibuprofen intermediate raw material. The purification method comprises the following steps: carrying out a primary distillation on synthetic liquid to obtain a primary material and recovered 4-methyl-1-pentene, then carrying out a second-stage distillation on the primary material to obtain a second-stage material and a recovered crude toluene product; and carrying out a third-stage distillation on the second-stage material to obtain isobutyl benzene and a recovered crude n-butylbenzene product. Embodiment results show that the purification method provided by the present disclosure is high in product recovery rate and high in product purity, the purity of isobutyl benzene is up to 99.99 wt %, the recovery rate is up to 99.9 wt %, the impurity content is not higher than 50 ppm.