Pyridine N-oxide derivatives useful as factor XIa inhibitors

The present invention is directed to pyridine N-oxide derivatives, stereoisomers, isotopologues, isotopomers and pharmaceutically acceptable salts thereof, pharmaceutical compositions containing said compounds and the use of said compounds in the treatment and/or prophylaxis of thromboembolic disord...

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Bibliographic Details
Main Authors Guo, Boying, Xu, Guozhang, Lu, Tianbao, Macielag, Mark J, Thieu, Tho V, Liu, Zhijie, Gaul, Micheal D, Zhang, Jing, Grant, Eugene B
Format Patent
LanguageEnglish
Published 14.11.2023
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The present invention is directed to pyridine N-oxide derivatives, stereoisomers, isotopologues, isotopomers and pharmaceutically acceptable salts thereof, pharmaceutical compositions containing said compounds and the use of said compounds in the treatment and/or prophylaxis of thromboembolic disorders, inflammatory disorders and diseases or conditions in which plasma kallikrein activity is implicated.
Bibliography:Application Number: US202217696926