Small-molecule PI5P4K alpha/beta inhibitors and methods of treatment using same

The present-disclosure relates to the discovery of novel 2-amino-dihydropteridinone compounds and analogues thereof, which are capable of inhibiting phosphatidylinositol phosphate kinases. In certain embodiments, the compounds of the present disclosure can be used to treat p53-null cancer in a subje...

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Bibliographic Details
Main Authors Chen, Song, Cianciulli, Agostino, Micheli, Fabrizio, Ha, Ya, Ellman, Jonathan, Tjin, Caroline Chandra, Beato, Claudia
Format Patent
LanguageEnglish
Published 03.10.2023
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The present-disclosure relates to the discovery of novel 2-amino-dihydropteridinone compounds and analogues thereof, which are capable of inhibiting phosphatidylinositol phosphate kinases. In certain embodiments, the compounds of the present disclosure can be used to treat p53-null cancer in a subject. In other embodiments, the compounds of the present disclosure can be used to treat metabolic disorders in a subject, including but not limited to type 2 diabetes and/or obesity.
Bibliography:Application Number: US201917267488