Anti-HLA-DQ2.5 antibody and its use for the treatment of celiac disease

The present invention relates to anti-HLA-DQ2.5 antibodies and its use for the treatment of celiac disease.The present invention provides anti-HLA-DQ2.5 antibodies that have been modified. The anti-HLA-DQ2.5 antibodies of the invention have binding activity to complexes formed by HLA-DQ2.5 and a glu...

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Bibliographic Details
Main Authors Ikawa, Yuri, Okura, Yuu, Mizoroki, Akihiko
Format Patent
LanguageEnglish
Published 29.08.2023
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Summary:The present invention relates to anti-HLA-DQ2.5 antibodies and its use for the treatment of celiac disease.The present invention provides anti-HLA-DQ2.5 antibodies that have been modified. The anti-HLA-DQ2.5 antibodies of the invention have binding activity to complexes formed by HLA-DQ2.5 and a gluten peptide, but have substantially no binding activity to complexes formed by HLA-DQ2.5 and an irrelevant peptide. Furthermore, the antibodies of the invention are shown to have inhibitory effects on T cell activation by gluten peptides.
Bibliography:Application Number: US202117477651