Apparatus, system and method for performing automated centrifugal separation

• Main Authors: Talebpour, Samad, Leonard, Stephen W, Etemad-Moghadam, Cyrus, Maaskant, Robert, Yasotharan, Sanjesh, Zahn, Alexander
• Format: Patent
• Language: English
• Published: 29.08.2023
• Subjects: ACTUATING-FLOATS; BEER; BIOCHEMISTRY; BLASTING; CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL ORCHEMICAL PROCESSES; CENTRIFUGES; CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE; CHEMISTRY; COCKS; COMPOSITIONS THEREOF; CULTURE MEDIA; DEVICES FOR VENTING OR AERATING; ENGINEERING ELEMENTS AND UNITS; ENZYMOLOGY; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVEFUNCTIONING OF MACHINES OR INSTALLATIONS; HEATING; LIGHTING; MECHANICAL ENGINEERING; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SEPARATION; SPIRITS; TAPS; THERMAL INSULATION IN GENERAL; TRANSPORTING; VALVES; VINEGAR; WEAPONS; WINE

Systems, methods and devices are provided for the automated centrifugal processing of samples. In some embodiments, an integrated fluidic processing cartridge is provided, in which a centrifugation chamber is fluidically interfaced, through a lateral surface thereof, with a microfluidic device, and wherein the integrated fluidic processing cartridge is configured to be inserted into a centrifuge for centrifugation. A cartridge interfacing assembly may be employed to interface with the integrated fluidic processing cartridge for performing various fluidic processing steps, such as controlling the flow of fluids into and out of the centrifugation chamber, and controlling the flow of fluids into the microfluidic device, and optionally for the further fluidic processing of fluids extracted to the microfluidic device. The integrated fluidic processing cartridge may include a supernatant chamber the extraction of a supernatant thereto, and a diluent chamber for diluting a suspension collected in the centrifugation chamber.