Inhibitors of receptor interacting protein kinase I for the treatment of disease

• Main Authors: Reyna, Naphtali, Lewis, Richard T, Ray, William J, Ramaswamy, Suyambu Kesava Vijayan, Cross, Jason, Hamilton, Matthew, Alvarez, Fernando
• Format: Patent
• Language: English
• Published: 08.08.2023
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

Disclosed herein are compounds which inhibit RIPK1, pharmaceutical compositions, and methods of treatment of RIPK1-mediated diseases, such as neurodegenerative disorders, inflammatory disorders, and cancer.