Bicyclic nitrogen-containing heterocyclic derivatives and pharmaceutical composition comprising the same

• Main Authors: Kai, Hiroyuki, Masuda, Koji, Ogawa, Tomoyuki, Kojima, Eiichi, Kobayashi, Naotake, Yamada, Toru, Sugiyama, Shuichi
• Format: Patent
• Language: English
• Published: 27.06.2023
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Provided are a novel compound having an antagonistic activity for the P2X7 receptor, and a pharmaceutical composition having an antagonistic activity for the P2X7 receptor. A compound represented by Formula (I):wherein Z1 is C(R4) or the like; R4 is a hydrogen atom or the like; Z2 is C(R5a)(R5a′) or the like; the dashed line represents the presence or absence of a bond; when the dashed line represents the presence of a bond, then R5a′ is absent; R5a and R5a′ are each independently a hydrogen atom or the like; Ring Q is a substituted or unsubstituted 5-membered non-aromatic heterocycle or the like; Y1 is O or the like; R2a is a group represented by the formula: -(C(R2a′)(R2b′))n-R1; R2b is a hydrogen atom or the like; R2a′ and R2b′ is each independently a hydrogen atom or the like; R1 is substituted or unsubstituted aromatic carbocyclyl or the like; X is N(R7a) or the like; R7a is a hydrogen atom or the like; R3 is substituted or unsubstituted aromatic carbocyclyl or the like; n is an integer from 0 to 4; and m is an integer from 0 to 4, or a pharmaceutically acceptable salt thereof.