MASP inhibitory compounds and uses thereof

The present invention relates to novel Mannose-binding lectin (MBL)-associated serine protease (MASP) inhibitory compounds, as well as analogues and derivatives thereof, to processes for the preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases...

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Bibliographic Details
Main Authors Glatz, Marie, Dreher, Jan, Bierer, Donald, Holton, Simon, Poethko, Thorsten, Zubov, Dmitry, Baumann, Lars, Neubauer, Thomas, Flamme, Ingo, Tersteegen, Adrian, Terjung, Carsten, Xiong, Jiancheng, Juhl, Cathleen, Qiu, Yibo
Format Patent
LanguageEnglish
Published 06.06.2023
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to novel Mannose-binding lectin (MBL)-associated serine protease (MASP) inhibitory compounds, as well as analogues and derivatives thereof, to processes for the preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of renal and cardiovascular disorders and of ischemia reperfusion injuries.
Bibliography:Application Number: US202017138447