Microfluidic devices and methods for delivering solutions to biological material

Disclosed herein are microfluidic devices and methods to deliver concentration gradients to biological material such as oocytes and embryos for the purpose of cryopreparation, cryopreservation, or thawing. Cryopreservation methods, such as vitrification, involve the use of cryoprotectants to reduce...

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Bibliographic Details
Main Authors Sales Fidalgo, Joana Alexandra, Horcajadas Almansa, José Antonio, Garcia Alonso, Daniel, Munne, Santiago, Cancio Villalonga, David, Dosda Munuera, Cristina, Matthys, Lionel, Carasa Ruiz, Pablo, Alvarez Arguelles, Sara
Format Patent
LanguageEnglish
Published 30.05.2023
Subjects
CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
PERFORMING OPERATIONS
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
TRANSPORTING
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Summary:Disclosed herein are microfluidic devices and methods to deliver concentration gradients to biological material such as oocytes and embryos for the purpose of cryopreparation, cryopreservation, or thawing. Cryopreservation methods, such as vitrification, involve the use of cryoprotectants to reduce formation of damaging ice crystals in cells during freezing. Microfluidic devices and methods described herein improve cell viability and efficiency during handling and cryopreservation of biological materials.
Bibliography:Application Number: US202117395572