Substituted pyrazolo[3,4-b]pyrazines as SHP2 phosphatase inhibitors

The present disclosure relates to compounds of formula (I) and pharmaceutical compositions thereof and methods for inhibiting the activity of SHP2 phosphatase with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating...

Full description

Saved in:
Bibliographic Details
Main Authors Therrien, Eric, Dahlgren, Markus Kristofer, Greisman, Jack Benjamin, Lescarbeau, André, Kelley, Elizabeth H, Murcko, Mark Andrew, Tang, Yong, Pierce, Levi Charles Thomas, Taylor, Alexander M, Maragakis, Paul, Shortsleeves, Kelley C, Giordanetto, Fabrizio, DiPietro, Lucian V, Walters, W. Patrick, Bhat, Sathesh
Format Patent
LanguageEnglish
Published 28.02.2023
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Online AccessGet full text

Cover

More Information
Summary:The present disclosure relates to compounds of formula (I) and pharmaceutical compositions thereof and methods for inhibiting the activity of SHP2 phosphatase with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with SHP2 deregulation with the compounds and compositions of the disclosure.
Bibliography:Application Number: US201816616361