Polynucleotides encoding interleukin-12 (IL12) and uses thereof
The present disclosure relates to polynucleotides comprising an open reading frame of linked nucleosides encoding human interleukin-12 (IL12), functional fragments thereof, and fusion proteins comprising IL12. In some embodiments, the open reading frame is sequence-optimized. In particular embodimen...
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Main Authors | , , , , , , , |
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Format | Patent |
Language | English |
Published |
07.02.2023
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Subjects | |
Online Access | Get full text |
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Summary: | The present disclosure relates to polynucleotides comprising an open reading frame of linked nucleosides encoding human interleukin-12 (IL12), functional fragments thereof, and fusion proteins comprising IL12. In some embodiments, the open reading frame is sequence-optimized. In particular embodiments, the disclosure provides sequence-optimized polynucleotides comprising nucleotides encoding the polypeptide sequence of human IL12, or sequences having high sequence identity with those sequence optimized polynucleotides. |
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Bibliography: | Application Number: US202217721583 |