Process for the preparation of bromodomain inhibitor

The present invention provides processes of synthesis and purification of a bromodomain inhibitor, Compound 1, which compound includes crystalline forms, amorphous forms, solvates, and hydrates thereof. Embodiments of the disclosure relate to chemical synthesis routes of Compound 1 that provide a sc...

Full description

Saved in:
Bibliographic Details
Main Authors Ferretti, Antonio Christian, Ruda, Antonio Maria, Philp, Steven, Traverse, John Fitzgerald, Alite, Hekla, Moseley, Jonathan, Yong, Kelvin Hin-Yeong, Primer, David
Format Patent
LanguageEnglish
Published 31.01.2023
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
Online AccessGet full text

Cover

More Information
Summary:The present invention provides processes of synthesis and purification of a bromodomain inhibitor, Compound 1, which compound includes crystalline forms, amorphous forms, solvates, and hydrates thereof. Embodiments of the disclosure relate to chemical synthesis routes of Compound 1 that provide a scalable method that results in highly pure final product. A further embodiment relates to methods to isolate the most stable polymorph of Compound 1 by crystallization from formic acid and water.
Bibliography:Application Number: US201917262642