Thermally sensitive protecting groups for cysteine, and manufacture and use thereof

In a preferred embodiment, there is provided a protecting group for protecting the thiol side chain of a cysteine residue, the protecting group comprising a Diels-Alder cycloadduct of a furan and a maleimide, and optionally, a linker interposed between the thiol side chain and the Diels-Alder cycloa...

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Bibliographic Details
Main Authors Trant, John Frederick, Hayward, John James, Chifor, Anthony Emanuel, Meister, Daniel, Taimoory, Seyedeh Maryamdokht, Dashti-Pour, Mohadeseh, Nasri, Sarah
Format Patent
LanguageEnglish
Published 24.01.2023
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Summary:In a preferred embodiment, there is provided a protecting group for protecting the thiol side chain of a cysteine residue, the protecting group comprising a Diels-Alder cycloadduct of a furan and a maleimide, and optionally, a linker interposed between the thiol side chain and the Diels-Alder cycloadduct.
Bibliography:Application Number: US202117468048