Methods of engineering human induced pluripotent stem cells to produce liver tissue

Methods are disclosed herein for producing human hepatocytes from human induced pluripotent stem cells. Also provided are transgenic rats for the expansion of human hepatocytes, such as those produced using the methods disclosed herein.

Saved in:
Bibliographic Details
Main Authors Takeishi, Kazuki, Soto-Gutierrez, Alejandro, Collin de l'Hortet, Alexandra Sylvie, Popovic, Branimir, Lepe, Jorge Guzman, Handa, Kan, Wang, Yang, Mashimo, Tomoji, Cervantes Alvarez, Eduardo
Format Patent
LanguageEnglish
Published 20.12.2022
Subjects
AGRICULTURE
ANIMAL HUSBANDRY
BEER
BIOCHEMISTRY
CARE OF BIRDS, FISHES, INSECTS
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
FISHING
FORESTRY
HUMAN NECESSITIES
HUNTING
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
NEW BREEDS OF ANIMALS
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR
SPIRITS
TRAPPING
VINEGAR
WINE
Online AccessGet full text

Cover

More Information
Summary:Methods are disclosed herein for producing human hepatocytes from human induced pluripotent stem cells. Also provided are transgenic rats for the expansion of human hepatocytes, such as those produced using the methods disclosed herein.
Bibliography:Application Number: US201816485771