Biofabricated material containing collagen fibrils

• Main Authors: Williamson, David Thomas, Purcell, Brendan Patrick, Dai, Lixin, Spinella, Stephen M, Congdon, Katherine Amy, Cassingham, Darryl Miles
• Format: Patent
• Language: English
• Published: 20.12.2022
• Subjects: AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F,C08G; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBONFILAMENTS; APPARATUS THEREFOR; BRAIDING; CARBONISING RAGS TO RECOVER ANIMAL FIBRES; CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS,THREADS, FIBRES, BRISTLES OR RIBBONS; CHEMICAL TREATMENT OF HIDES, SKINS OR LEATHER, e.g. TANNING,IMPREGNATING, FINISHING; CHEMICAL TREATMENT OF NATURAL FILAMENTARY OR FIBROUS MATERIALTO OBTAIN FILAMENTS OR FIBRES FOR SPINNING; CHEMISTRY; COMPOSITIONS BASED THEREON; COMPOSITIONS FOR TANNING; COTTON-WOOL; DYEING LEATHER, FURS, OR SOLID MACROMOLECULAR SUBSTANCES INANY FORM; DYEING OR PRINTING TEXTILES; FABRICS MADE BY SUCH PROCESSES OR APPARATUS, e.g. FELTS,NON-WOVEN FABRICS; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR; FLEXIBLE SHEET MATERIAL NOT OTHERWISE PROVIDED FOR; GENERAL PROCESSES OF COMPOUNDING; HIDES; KNITTING; LACE-MAKING; LAUNDERING; LAYERED PRODUCTS; LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT ORNON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM; LEATHER; MAKING TEXTILE FABRICS, e.g. FROM FIBRES OR FILAMENTARYMATERIAL; METALLURGY; NATURAL OR ARTIFICIAL THREADS OR FIBRES; NON-WOVEN FABRICS; ORGANIC CHEMISTRY; ORGANIC MACROMOLECULAR COMPOUNDS; PELTS; PEPTIDES; PERFORMING OPERATIONS; SKINS; SPINNING; TEXTILES; THEIR PREPARATION OR CHEMICAL WORKING-UP; TRANSPORTING; TREATMENT OF TEXTILES OR THE LIKE; TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS,FABRICS, FEATHERS, OR FIBROUS GOODS MADE FROM SUCH MATERIALS; TRIMMINGS; WADDING; WALL, FLOOR OR LIKE COVERING MATERIALS, e.g. LINOLEUM,OILCLOTH, ARTIFICIAL LEATHER, ROOFING FELT, CONSISTING OF AFIBROUS WEB COATED WITH A LAYER OF MACROMOLECULARMATERIAL; WORKING-UP

A biofabricated material comprising a network of crosslinked collagen fibrils produced from recombinant collagen that contains substantially no 3-hydroxyproline residues is disclosed. This material is composed of collagen which is also a major component of natural leather and is produced by a process of fibrillation of collagen molecules into fibrils, crosslinking the fibrils and lubricating the crosslinked fibrils. Unlike natural leathers, this biofabricated material exhibits non-anisotropic (not directionally dependent) physical properties, for example, a sheet of biofabricated material can have substantially the same elasticity or tensile strength when stretched or stressed in different directions. Unlike natural leather, it has a uniform texture that facilitates uniform uptake of dyes and coatings. Aesthetically, it produces a uniform and consistent grain for ease of manufacturability. It can have substantially identical grain, texture and other aesthetic properties on both sides distinct from natural leather where the grain increases from one side (e.g., distal surface) to the other (proximal inner layers).