Naphthyridinone derivatives and their use in the treatment of arrhythmia

• Main Authors: Barbe, Guillaume, Ma, Fupeng, Mo, Ruowei, Yamada, Ken, Gulgeze Efthymiou, Hatice Belgin, Parker, David Thomas, Bebernitz, Gregory Raymond, Peukert, Stefan, Smith, Nichola, Peng, Yunshan, Liao, Lv, Yasoshima, Kayo, Geng, Sicong
• Format: Patent
• Language: English
• Published: 20.12.2022
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof;Wherein R1, R3-R6, X2 and X3 are as defined herein, a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.