MTA-cooperative PRMT5 inhibitors

The present invention relates to compounds that inhibit Protein Arginine N-Methyl Transferase 5 (PRMT5) activity. In particular, the present invention relates to compounds of Formula (I)to pharmaceutical compositions comprising compounds of Formula (I) and to methods of use thereof, such as methods...

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Bibliographic Details
Main Authors Smith, Christopher Ronald, Kuehler, Jon, Lawson, John David, Ketcham, John Michael, Burns, Aaron Craig, Bobinski, Thomas P, Marx, Matthew Arnold, Ivetac, Anthony, Kulyk, Svitlana
Format Patent
LanguageEnglish
Published 08.11.2022
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HETEROCYCLIC COMPOUNDS
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:The present invention relates to compounds that inhibit Protein Arginine N-Methyl Transferase 5 (PRMT5) activity. In particular, the present invention relates to compounds of Formula (I)to pharmaceutical compositions comprising compounds of Formula (I) and to methods of use thereof, such as methods of treating cancer using the compounds of Formula (I) and pharmaceutical compositions comprising those compounds.
Bibliography:Application Number: US202017018738