Cyclic dinucleotides as sting agonists

Disclosed are compounds, compositions and methods for treating viral infections, diseases, syndromes, or disorders that are affected by the modulation of STING. Such compounds are represented by Formula (I) as follows:wherein R1A, R1B, R1c, B1, R2A, and R2B are defined herein.

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Bibliographic Details
Main Authors Edwards, James Patrick, Lu, Tianbao, Laquerre, Sylvie, Zhong, Minghong, Richter, Mark, Connolly, Peter, Thatikonda, Santhosh Kumar, Wang, Guangyi, Bignan, Gilles, Beigelman, Leonid, Emanuel, Stuart
Format Patent
LanguageEnglish
Published 18.10.2022
Subjects
CHEMISTRY
DERIVATIVES THEREOF
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SUGARS
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Summary:Disclosed are compounds, compositions and methods for treating viral infections, diseases, syndromes, or disorders that are affected by the modulation of STING. Such compounds are represented by Formula (I) as follows:wherein R1A, R1B, R1c, B1, R2A, and R2B are defined herein.
Bibliography:Application Number: US201715820592