Macrocyclic chlorine substituted indole derivatives

The present invention relates to macrocyclic indole derivatives of general formula (I):in which R1, R2, R3, R4, R5, R6, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations compris...

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Main Authors Johannes, Sarah Anna Liesa, Fitzgerald, Mark, Mengel, Anne, Furst, Laura, Werbeck, Nicolas, Wei, Guo, Payne, Daniel, Serrano-Wu, Michael H, McCarren, Patrick R, Buchgraber, Philipp, Klar, Ulrich, Thede, Kai, Lazarski, Kiel, Kaulfuss, Stefan, Fernandez-Montalvan, Amaury Ernesto, McKinney, David, Ferrara, Steven J, Pesnot, Thomas, Wilson, Craig, Nowak-Reppel, Katrin, Christ, Clara, Rauh, Ulrike, Moenning, Ursula, Kuhnke, Joachim, Mortier, Jérémie Xavier, Lemke, Chris, Nasveschuk, Christopher, Harvey, Rebecca Ann
Format Patent
LanguageEnglish
Published 20.09.2022
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention relates to macrocyclic indole derivatives of general formula (I):in which R1, R2, R3, R4, R5, R6, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.
Bibliography:Application Number: US201816764675