Modulators of cystic fibrosis transmembrane conductance regulator

• Main Authors: Gross, Raymond Stanley, Clemens, Jeremy J, Cleveland, Thomas, Binch, Hayley Marie, Uy, Johnny, Nicholls, Georgia McGaughey, Marelius, Gulin Erdogan, Termin, Andreas P, Krenitsky, Paul John, Pierre, Fabrice Jean Denis, Khatuya, Haripada, Lin, Chun-Chieh, Silina, Alina, Conroy, Erica, McCartney, Jason, Frieman, Bryan A, Coon, Timothy Richard, Bear, Brian Richard, Arumugam, Vijayalaksmi, Grootenhuis, Peter Diederik Jan, Joshi, Pramod Virupax, Zhou, Jinglan, Miller, Mark Thomas, Melillo, Vito, Anderson, Corey, Hadida-Ruah, Sara Sabina
• Format: Patent
• Language: English
• Published: 30.08.2022
• Subjects: BABY COMFORTERS; CHEMISTRY; CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICALPURPOSES; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; DEVICES FOR RECEIVING SPITTLE; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGINGPHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL ORADMINISTERING FORMS; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The present invention features a compound of formula I:or a pharmaceutically acceptable salt thereof, where R1, R2, R3, W, X, Y, Z, n, o, p, and q are defined herein, for the treatment of CFTR mediated diseases, such as cystic fibrosis. The present invention also features pharmaceutical compositions, method of treating, and kits thereof.