Roundabout (Robo) receptor inhibitors and uses thereof

The present invention, in some embodiments thereof, relates to inhibitory compositions binding to the ectodomain of a Roundabout (Robo) receptor and to the use of same for downregulating Robo-mediated signaling. In particular, the present invention provides moieties that bind to and prevent dimeriza...

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Bibliographic Details
Main Authors Opatowsky, Yarden, Yom-Tov, Galit, Barak-Fucks, Reut, Guez-Haddad, Julia
Format Patent
LanguageEnglish
Published 09.08.2022
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention, in some embodiments thereof, relates to inhibitory compositions binding to the ectodomain of a Roundabout (Robo) receptor and to the use of same for downregulating Robo-mediated signaling. In particular, the present invention provides moieties that bind to and prevent dimerization of an Ig-like Robo receptor ectodomain, thereby inhibiting Robo receptor activity.
Bibliography:Application Number: US201816641263