Method for treating an autoimmune neurological disease and/or neurodegenerative disease and pharmaceutical formulations for a liquid dosage form and a controlled release dosage form

• Main Authors: Wen, Shu-Fang, Lin, Meng-Nan, Huang, Kuo-Kuei, Yang, Ya-Yan, Lu, Chu-Hsun, Lu, I-Huang, Kuo, Zong-Keng, Lee, Tze-Chung, Liaw, Jia-Horng, Lin, Pei-Hsin, Pan, I-Hong
• Format: Patent
• Language: English
• Published: 02.08.2022
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

A method for treating an autoimmune neurological disease and/or a neurodegenerative disease is provided. The method includes administering an effective amount of at least one compound having Formula (I), Formula (II) or Formula (III), or its geometric isomer, enantiomer or diastereomer to a subject in need thereof:wherein is a single or double bond, X is NCH3 or CH2, Y is null, O or N, Z is O or N, R1 is H, OH, and R2 is null, H, C1-C8 alkyl, -(C═O)-alkyl, -(C═O)-aryl, -(C═O)-alkyl-aryl, -(C═O)-heteroaryl, cycloalkyl or heterocycloalkyl, which optionally substituted by one or more of -OH, -NO2, -NH2, -NR3R4, carbonyl, alkoxyl, alkyl or -OCF3, wherein R3 and R4 independently are H, alkyl, -SO2CH3, -(C═O)-CH3 or -(C═O)-NH2.