Amino acid compounds with unbranched linkers and methods of use

The invention relates to compounds of formula (A):or a salt thereof, wherein R1, R2, R5a, R5b, R6a, R6b, R7a, R7b, R8a, R8b, R9a, R9b, R10a, R10b, R11a, R11b, R21, n, and G are as described herein. Compounds of formula (I) and pharmaceutical compositions thereof are αVβ6 integrin inhibitors that are...

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Bibliographic Details
Main Authors Bailey, Christopher, Reilly, Maureen, Leftheris, Katerina, Finkelstein, Darren, Cooper, Nicole, Cha, Jacob
Format Patent
LanguageEnglish
Published 26.07.2022
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention relates to compounds of formula (A):or a salt thereof, wherein R1, R2, R5a, R5b, R6a, R6b, R7a, R7b, R8a, R8b, R9a, R9b, R10a, R10b, R11a, R11b, R21, n, and G are as described herein. Compounds of formula (I) and pharmaceutical compositions thereof are αVβ6 integrin inhibitors that are useful for treating fibrosis such as idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP).
Bibliography:Application Number: US201916455490