Spiropiperidine allosteric modulators of nicotinic acetylcholine receptors

The present disclosure relates to compounds of formula I that are useful as modulators of 7 nAChR, compositions comprising such compounds, and the use of such compounds for preventing, treating, or ameliorating disease, particularly disorders of the central nervous system such as cognitive impairmen...

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Main Authors Greshock, Thomas J, Leavitt, Kenneth J, Crowley, Brendan M, Fells, James I, Bell, Ian M, Rada, Vanessa L, Chobanian, Harry R, Guiadeen, Deodial G, Campbell, Brian T
Format Patent
LanguageEnglish
Published 17.05.2022
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present disclosure relates to compounds of formula I that are useful as modulators of 7 nAChR, compositions comprising such compounds, and the use of such compounds for preventing, treating, or ameliorating disease, particularly disorders of the central nervous system such as cognitive impairments in Alzheimer's disease, Parkinson's disease, and schizophrenia, as well as for L-DOPA induced-dyskinesia and inflammation (I).
Bibliography:Application Number: US201917049653