Substituted pyrazino[2,3-b]pyrazines as mTOR kinase inhibitors

• Main Authors: Riggs, Jennifer, Sapienza, John, Harris, Roy L, Papa, Patrick, Parnes, Jason, Shevlin, Graziella I, Perrin-Ninkovic, Sophie, Lee, Branden Gingsee, Elsner, Jan, Tehrani, Lida, Zhao, Jingjing, Mortensen, Deborah, Packard, Garrick K
• Format: Patent
• Language: English
• Published: 05.04.2022
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

Provided herein are Heteroaryl Compounds having the following structure:wherein R1-R4 are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing cancer, inflammatory conditions, immunological conditions, neurodegenerative diseases, diabetes, obesity, neurological disorders, age-related diseases, or cardiovascular conditions, comprising administering an effective amount of a Heteroaryl Compound to a patient in need thereof.Further provided herein are methods for preparing a compound of formula (I),the method comprising contacting a compound of formula (III)with a compound of the following formula: R1-Y,in a solvent, in the presence of a palladium catalyst, wherein said contacting occurs in the presence of a base, wherein R1-R4, Y, the palladium catalyst and the base are as defined herein.