System and method with reflective fiducials for locating or registering locations receiving biological samples in successive cycles of fluorescent imaging

Fiducial markers are provided on patterned arrays of the type that may be used for molecular analysis, such as sequencing. The fiducial markers may have configurations that enhance their detection in image or detection data, that facilitate or improve processing, that provide encoding of useful info...

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Bibliographic Details
Main Authors Bowen, M. Shane, Nemiroski, Alex, Tanner, Stephen, Vieceli, John S, Chan, Danny Yuan, Samiee, Kevan, Belitz, Paul, Venkatesan, Bala Murali K, Langlois, Robert, Han, Hui
Format Patent
LanguageEnglish
Published 01.03.2022
Subjects
CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
PERFORMING OPERATIONS
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
PHYSICS
TESTING
TRANSPORTING
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Summary:Fiducial markers are provided on patterned arrays of the type that may be used for molecular analysis, such as sequencing. The fiducial markers may have configurations that enhance their detection in image or detection data, that facilitate or improve processing, that provide encoding of useful information, and so forth. Examples of the fiducial markers may include features and materials that are provided on or in the support of a patterned array and that return at least a portion of incident light by reflection. The fiducial markers may form gratings or other encoding configurations that assist in image processing, alignment, or other aspects of processing of the patterned array.
Bibliography:Application Number: US201816482653