Small molecule inhibitors of NF-κB inducing kinase

The present invention relates to compounds that inhibit NIK and pharmaceutical compositions comprising such compounds and methods of using the same. These compounds and pharmaceutical compositions are envisaged to be useful for preventing or treating diseases such as cancer (such as B-cell malignanc...

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Bibliographic Details
Main Authors Jones, William M, Krawczuk, Paul J, Kreutter, Kevin D, Eccles, Wendy, Hack, Michael D, Barbay, J. Kent, Chai, Wenying, Herrmann, Aaron T, Lebsack, Alec D, Pippel, Daniel J, Rovira, Alexander R, Wolin, Ronald L
Format Patent
LanguageEnglish
Published 22.02.2022
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The present invention relates to compounds that inhibit NIK and pharmaceutical compositions comprising such compounds and methods of using the same. These compounds and pharmaceutical compositions are envisaged to be useful for preventing or treating diseases such as cancer (such as B-cell malignancies including leukemias, lymphomas and myeloma), inflammatory disorders, autoimmune disorders, immunodermatologic disorders such as palmoplantar pustulosis and hidradenitis suppurativa, and metabolic disorders such as obesity and diabetes.
Bibliography:Application Number: US202016887889