Pyrrolo-pyrimidine derivative compound, preparation method therefor, and pharmaceutical composition comprising same compound as effective ingredient for preventing or treating protein kinase-related disease

• Main Authors: Ko, Eunhwa, Park, Jin-Hee, Kim, Sang Bum, Lee, Seung Hoon, Park, Jong Bae, Kim, Nam Doo, Bae, Jae Hyun, Kim, Dayea, Kim, So Young, Ko, Yi Kyung, Lee, Yunho, Jang, Tae-ho, Lee, Sun-Hwa, Kang, Seock Yong, Nam, Do-Hyun, Choi, Hwan Geun, Hong, Eunmi, Son, Jung Beom, Cho, Joong-heui, Lee, Seungyeon, Lee, Sun Joo
• Format: Patent
• Language: English
• Published: 28.12.2021
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to a novel pyrrolo-pyrimidine derivative compound, a preparation method therefor, and a pharmaceutical composition comprising the same compound as an effective ingredient for preventing or treating a protein kinase-related disease. The compound represented by Chemical Formula 1 according to the present invention, an optical isomer thereof, or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same as an effective ingredient has outstanding inhibitory activity against LRRK2 kinase and against phosphorylation in the NIH-3T3 cell line, which is an LRRK2-expressing cell line, and NCC01 and 448T cell lines, which are both derived from patients with brain tumors. Verified to have inhibitory activity against various protein kinases in addition to LRRK2, the compound can find effective applications in the treatment or prevention of protein kinase-related diseases.