3-(1H-pyrazol-4-yl)pyridine allosteric modulators of the M4 muscarinic acetylcholine receptor

The present invention is directed to pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric...

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Main Authors Zhang, Fengqi, Gao, Xiaolei, Deng, Qiaolin, Bao, Jianming, Egbertson, Melissa, Knowles, Sandra L, Harrison, Scott Timothy, Lo, Michael Man-Chu, Tellers, David M, Rudd, Michael T, Li, Chunsing, Acton, III, John J, Selyutin, Oleg, Ferguson, II, Ronald, Na, Meng, Mazzola, Jr., Robert D, Tong, Ling, Meng, Zhaoyang
Format Patent
LanguageEnglish
Published 19.10.2021
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The present invention is directed to pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.
Bibliography:Application Number: US201816621959