Heteroaromatic derivatives as NIK inhibitors

The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a mammal, and in particular to inhibitors of NF-κB-inducing kinase (NIK-also known as MAP3K14) useful for treating diseases such as cancer, inflammatory disorders, metabolic disorders and autoimmune disor...

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Bibliographic Details
Main Authors Querolle, Olivier Alexis Georges, Meerpoel, Lieven, Kulagowski, Janusz Jozef, Macleod, Calum, Stansfield, Ian, Jacoby, Edgar, Gross, Gerhard Max, Green, Simon Richard, Hynd, George, Mann, Samuel Edward, Ligny, Yannick Aime Eddy
Format Patent
LanguageEnglish
Published 05.10.2021
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a mammal, and in particular to inhibitors of NF-κB-inducing kinase (NIK-also known as MAP3K14) useful for treating diseases such as cancer, inflammatory disorders, metabolic disorders and autoimmune disorders. The invention is also directed to pharmaceutical compositions comprising such compounds, and to the use of such compounds or pharmaceutical compositions for the prevention or treatment of diseases such as cancer, inflammatory disorders, metabolic disorders including obesity and diabetes, and autoimmune disorders.
Bibliography:Application Number: US201716309059