Kappa opioid receptor antagonists and products and methods related thereto

• Main Authors: Urbano, Mariangela, Laxamana, Candace Mae, Jones, Robert M, Roberts, Edward, Turtle, Eric Douglas, Rosen, Hugh, Zhao, Xianrui, Guerrero, Miguel A
• Format: Patent
• Language: English
• Published: 21.09.2021
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Compounds are provided that antagonize the kappa-opioid receptor (KOR) and products containing such compounds, as well as to methods of their use and synthesis. Such compounds have the structure of Formula (I), or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope or salt ther...