Kappa opioid receptor antagonists and products and methods related thereto

Compounds are provided that antagonize the kappa-opioid receptor (KOR) and products containing such compounds, as well as to methods of their use and synthesis. Such compounds have the structure of Formula (I), or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope or salt ther...

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Bibliographic Details
Main Authors Urbano, Mariangela, Laxamana, Candace Mae, Jones, Robert M, Roberts, Edward, Turtle, Eric Douglas, Rosen, Hugh, Zhao, Xianrui, Guerrero, Miguel A
Format Patent
LanguageEnglish
Published 21.09.2021
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Compounds are provided that antagonize the kappa-opioid receptor (KOR) and products containing such compounds, as well as to methods of their use and synthesis. Such compounds have the structure of Formula (I), or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope or salt thereof:wherein X, Y, R1, R2, R4, R5 R6, R7, R8 and R11 are as defined herein.
Bibliography:Application Number: US202016846136