Process and intermediates for the synthesis of obeticholic acid and derivatives thereof

A process for the preparation of obeticholic acid and derivatives thereof by:(a) hydrogenation of the double bond and reductive opening of the epoxide of a compound of formula (II) or a salt or solvate thereofto obtain a compound of formula (IIIa) and/or (IIIb), or salts or solvates thereofand(b) co...

Full description

Saved in:
Bibliographic Details
Main Authors Cordovilla Losada, Carlos, Pérez Encabo, Alfonso, Herráiz Sierra, Ignacio, Fernández Sainz, Yolanda, Turiel Hernandez, José Angel
Format Patent
LanguageEnglish
Published 31.08.2021
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
STEROIDS
Online AccessGet full text

Cover

More Information
Summary:A process for the preparation of obeticholic acid and derivatives thereof by:(a) hydrogenation of the double bond and reductive opening of the epoxide of a compound of formula (II) or a salt or solvate thereofto obtain a compound of formula (IIIa) and/or (IIIb), or salts or solvates thereofand(b) conversion of a compound of formula (IIIa) and/or a compound of formula (IIIb), or a salt or solvate thereof, into a compound of formula (I), or a salt or solvate thereof
Bibliography:Application Number: US201816632304