Triazolopyridine inhibitors of myeloperoxidase

The present invention provides compounds of Formula (I). wherein A and Z are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are myeloperoxidase (MPO) inhibitors and may be useful for the treatment and/or prophylaxis of atherosclerosis, heart...

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Bibliographic Details
Main Authors Shaw, Scott A, Vokits, Benjamin P, Smallheer, Joanne M, Hu, Carol Hui, Valente, Meriah Neissel, Halpern, Oz Scott
Format Patent
LanguageEnglish
Published 13.07.2021
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The present invention provides compounds of Formula (I). wherein A and Z are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are myeloperoxidase (MPO) inhibitors and may be useful for the treatment and/or prophylaxis of atherosclerosis, heart failure, chronic obstructive pulmonary disease (COPD), and related diseases.
Bibliography:Application Number: US201716083951