Bicyclic [4,6,0] hydroxamic acids as HDAC inhibitors

• Main Authors: Lancia, Jr., David R, Ng, Pui Yee, Rudnitskaya, Aleksandra, Zheng, Xiaozhang
• Format: Patent
• Language: English
• Published: 22.12.2020
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The present invention relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with HDAC6, having a Formulae I or Formula II:where R, L, X1, X2, X3, X4, X5, Y1, Y2, Y3, and Y4 are described herein.