Process for the conjugation of a peptide or protein with a reagent comprising a leaving group including a portion of PEG

The invention relates to novel conjugating reagents capable of reaction with at least one nucleophile present in a peptide or protein, which contain at least one leaving group which is lost on reaction with said nucleophile, in which the leaving group includes a portion -(CH2CH2O)n-, in which n is a...

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Bibliographic Details
Main Authors Godwin, Antony, Badescu, George, Bird, Matthew, Morris, David, Frigerio, Mark, Bryant, Penny
Format Patent
LanguageEnglish
Published 17.11.2020
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The invention relates to novel conjugating reagents capable of reaction with at least one nucleophile present in a peptide or protein, which contain at least one leaving group which is lost on reaction with said nucleophile, in which the leaving group includes a portion -(CH2CH2O)n-, in which n is a number of six or more; and novel processes for the preparation of conjugates containing peptides or proteins made using such reagents.
Bibliography:Application Number: US201515517971